Jones Energy CEO wants to go public

Jonny Jones is the founder, chairman and CEO of Jones Energy Ltd.

Editor?s note: This is part of a series of articles on the winners of Ernst & Young?s 2012 Entrepreneurs Of The Year contest. Interviews and Q&As done with other winners can be found here.

Jonny Jones founded Jones Energy in 1988 with the Jones Family from Albany, Texas.

With family roots in the petroleum industry dating back to the 1920s, Jones is a third generation explorationist with more than 20 years of experience focusing on the mid-continent region of the United States. Through his direction, Jones Energy resurrected natural gas exploration of Permian reservoirs in the Texas Panhandle using 3D seismic and horizontal drilling.

Jones Energy has noted discoveries in Hansford, Hutchinson, Gray and Lipscomb counties in Texas along with additional activity in Oklahoma, New Mexico, Louisiana and West Virginia. Jones was formerly a production geologist with Standard Oil/British Petroleum in Oklahoma City, Dallas and Houston. He serves on the advisory council of the University of Oklahoma?s School of Geology and Geophysics, and he has been actively involved in fundraising efforts there. He is active in the American Association of Petroleum Geologists, Independent Petroleum Association of America, and Texas Independent Producers and Royalty Owners Association. He holds a bachelor?s in geology from the University of Oklahoma and a master?s in geology from the University of Texas at Austin.

What's the best advice you can offer an aspiring entrepreneur?

Follow your passion. Find something you are passionate about and go for it. Passion persuades, and with passion you will be a magnate for other great people who will be essential for you to achieve success

What?s the secret to your company?s success?

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New trial requested in Hudson family killings

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New brain target for appetite control identified

ScienceDaily (June 7, 2012) ? Researchers at Columbia University Medical Center (CUMC) have identified a brain receptor that appears to play a central role in regulating appetite. The findings, published June 7 in the online edition of Cell, could lead to new drugs for preventing or treating obesity.

"We've identified a receptor that is intimately involved in regulating food intake," said study leader Domenico Accili, MD, professor of Medicine at CUMC. "What is especially encouraging is that this receptor is belongs to a class of receptors that turn out to be good targets for drug development, making it a highly 'druggable' target. In fact, several existing medications already seem to interact with this receptor. So, it's possible that we could have new drugs for obesity sooner rather than later."

In their search for new targets for obesity therapies, scientists have focused on the hypothalamus, a tiny brain structure that regulates appetite. Numerous studies suggest that the regulatory mechanism is concentrated in neurons that express a neuropeptide, or brain modulator, called AgRP. But the specific factors that influence AgRP expression are not known.

The CUMC researchers found new clues to appetite control by tracing the actions of insulin and leptin. Both hormones are involved in maintaining the body's energy balance, and both are known to inhibit AgRP. "Surprisingly, blocking either the insulin or leptin signaling pathway has little effect on appetite," says Dr. Accili. "We hypothesized that both pathways have to be blocked simultaneously in order to influence feeding behavior."

To test their hypothesis, the researchers created a strain of mice whose AgRP neurons lack a protein that is integral to both insulin and leptin signaling. As the researchers hypothesized, removing this protein -- Fox01 -- had a profound effect on the animals' appetite. "Mice that lack Fox01 ate less and were leaner than normal mice," said lead author Hongxia Ren, PhD, associate research scientist in Medicine. "In addition, the Fox01-deficient mice had better glucose balance and leptin and insulin sensitivity -- all signs of a healthier metabolism."

Since Fox01 is a poor drug target, the researchers searched for other ways to inhibit the action of this protein. Using gene-expression profiling, they found a gene that is highly expressed in mice with normal AgRP neurons but is effectively silenced in mice with Fox01-deficient neurons. That gene is Gpr17 (for G-protein coupled receptor 17), which produces a cell-surface receptor called Gpr17.

To confirm that the receptor is involved in appetite control, the researchers injected a Gpr17 activator into normal mice, and their appetite increased. Conversely, when the mice were given a Gpr17 inhibitor, their appetite decreased. Similar injections had no effect on Fox01-deficient mice.

According to Dr. Accili, there are several reasons why Gpr17, which is also found in humans, would be a good target for anti-obesity medications. Since Grp17 is part of the so-called G-protein-coupled receptor family, it is highly druggable. About a third of all existing drugs work through G-protein-coupled receptors. In addition, the receptor is abundant in AgRP neurons but not in other neurons, which should limit unwanted drug side effects.

Dr. Accili and Dr. Ren's paper is titled, "G protein-coupled purinergic receptor GPR17 mediates orexigenic effects of FoxO1 in AgRP neurons." The other contributors are Ian J. Orozco (CUMC), Ya Su (Albert Einstein College of Medicine, Bronx, NY), Shigetomo Suyama (Yale University School of Medicine), Roger Guti?rrez-Ju?rez (Einstein), Tamas L. Horvath (Yale), Sharon L. Wardlaw (CUMC), Leona Plum (CUMC), and Ottavio Arancio (CUMC).

The study was supported by grants from the National Institutes of Health (DK58282, DK57539, DK80003, DK45024, NS49442, and DK63608).

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Story Source:

The above story is reprinted from materials provided by Columbia University Medical Center, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Hongxia Ren, Ian?J. Orozco, Ya Su, Shigetomo Suyama, Roger Guti?rrez-Ju?rez, Tamas?L. Horvath, Sharon?L. Wardlaw, Leona Plum, Ottavio Arancio, Domenico Accili. FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake. Cell, 2012; 149 (6): 1314 DOI: 10.1016/j.cell.2012.04.032

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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'SWAT-ting' attacks on bloggers prompt call for investigation

A number of conservative bloggers allege they have been targeted through the use of harassment tactics such as SWAT-ting (fooling 911 operators into sending emergency teams to their homes), in retaliation for posts they have written, and now Sen. Saxby Chambliss, R-Ga., has stepped into the matter. He has sent a letter to Attorney General Eric Holder urging him to investigate the SWAT-ting cases to see if federal laws have been violated.

"I am writing with concern regarding recent reports that several members of the community of online political commentators have been targeted with harassing and frightening actions. Any potentially criminal action that incites fear, seeks to silence a dissenting opinion, and collaterally wastes the resources of law enforcement should be given close scrutiny at all levels," Chambliss wrote in the letter.

"Regardless of any potential political differences that may exist, threats and intimidation have no place in our national political discourse. Those who choose to enter into that political discourse should not have to worry about potential threats to their or their family's safety," Chambliss continued.? "While I am certain that local law enforcement is reviewing each of these instances, I am asking you to please look into each of these cases as well to determine if any federal laws may have been violated. Future targets of SWAT-ting, whether engaged in political speech or not, may not be so fortunate as to escape physical harm."

ABC News spoke with two prominent conservative bloggers who were victims of SWAT-ting, a hoax tactic used by some hackers to infiltrate a victim's phone system, often through voice over IP (VOIP) technology to make calls appear as if they are coming from a residence. The perpetrators call police to report a violent crime at that home to which the police respond, sometimes with SWAT teams.

Just after midnight on July 1, 2011, Patrick Frey, a deputy District Attorney in Los Angeles and a conservative blogger who writes under the name "Patterico," heard a pounding at his door as sheriff's deputies arrived to investigate a call from Frey's home about a man who claimed he had killed his wife. But no one in Frey's home had been killed, and no one had made a phone call to the police.

"It's a phone call that could have gotten me killed," Frey wrote on his blog about the incident.

Frey was cuffed by police while they woke up his wife, who was asleep in their room, and questioned her about the safety of the children.? Helicopters swarmed overhead with searchlights as the sheriff's deputies investigated.

Frey told ABC News he received email threats prior to the SWAT-ting incident.

Late last month, Erick Erickson, the editor of the conservative site RedState.com, was the victim of the same type of targeting. He had written about Frey's case just a few days before.

Erickson sat at home in Macon, Georgia with his family while his children played outside over Memorial Day weekend when two sheriff's deputies drove to the house after receiving a phone call about Erickson allegedly shooting his wife.

"My first thought was, 'What have the kids done?'" Erickson said after seeing the police car outside his home.? "The police officer approached me in the driveway and said it was a call about an accidental shooting.? According to the 911 call, the person claimed I had killed my wife."

Erickson, who said he has received other types of threats in the past, had alerted the sheriff's department after Frey's experience in case he became the victim of a similar occurrence.

The Bibb County District Attorney's office in Georgia currently is investigating the case and could not offer comment on it.? Asked who he suspected was responsible for the phone call to police, Erickson declined to speculate.

But several conservative bloggers have been vocal about who they believe is responsible for the SWAT-tings and other forms of harassment - Brett Kimberlin, a man who was convicted of a series of bombings in Speedway, Indiana in the 1980s and made headlines in 1988 when he claimed to have once sold marijuana to then-vice presidential candidate Dan Quayle.

The group of conservative bloggers organized "Everybody Blog About Brett Kimberlin Day" on May 25, during which they urged the blogging community to write about the actions of Kimberlin.

Kimberlin, who is now the director of a non-profit organization called Justice Through Music, told ABC News that he did not commit or ask anyone to conduct the SWAT-ting hoaxes that were perpetrated against Erickson and Frey.

"Of course not, it's ridiculous.? It's totally irresponsible for them to even say this," Kimberlin told ABC News.?? "There is no truth to anything about the SWAT-ting."

But some conservative bloggers contend Kimberlin and his associates are responsible for other forms of harassment as well. ?Robert Stacy McCain, a contributor to the American Spectator and founder of The Other McCain Blog, wrote about Kimberlin, and shortly after, his wife's place of employment received a phone call from Kimberlin accusing McCain of harassment. ?Based on Kimberlin's ability to find his wife's employer, McCain became concerned Kimberlin also knew the location of his home, so the McCain family relocated to an undisclosed location.

"If I was going to continue doing this story, I?couldn't?do it from my home," McCain told ABC News.?"This kind of intimidation - it's a threat to protected first amendment expression."

"It's being treated as these are just bloggers playing around on Twitter, but this is serious business.? It's much more serious I think than most people now realize," McCain said.

Ali Akbar, the president of the National Blogger's Club, an organization established to support bloggers, recently was targeted by an anonymous website which posted the address of his mother's home in Forth Worth, Texas, along with a picture of the house. Akbar and other bloggers believe the website, "Breitbart Unmasked," is linked to Kimberlin.

The National Blogger's Club recently started a relief fund to help ease the financial woes of bloggers who are undergoing lawsuits, including one lawsuit by Kimberlin against blogger Aaron Walker, and Akbar believes the anonymous post of his mother's home address was a response to the creation of this fund.

"They decided to take this from a discussion about me trying to help some members of my club, and they tried to disable us," Akbar said.

Akbar and his mother are cooperating with the Tarrant County District Attorney's office regarding the incident.

Kimberlin denied he was responsible for the post, even saying that he does not maintain any online presence and said he and his family have been victims of threats themselves and accused the bloggers of constructing a "false narrative" about him.

"I don't blog, I don't comment, I don't tweet on any blogs at all.? This is a right-wing attack on me and my organizations and it's a smear job. It's a swift boat action against us," Kimberlin said. "What they're doing is an obstruction of justice and it's defamatory.? We're cooperating with the authorities in this matter.? They have engaged in a massive smear campaign against us that has resulted in death threats to me and my family and to others associated with us."

The FBI has investigated a number of SWAT-ting incidents in the past.? In 2009, Carlton Nalley was sentenced to nine years in federal prison after pleading guilty to offenses related to a SWAT-ting conspiracy in Fort Worth, Texas.

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Sony launches web store for e-Books, Android app also gets refresh

Sony has decided to join the web-based shopping party, launching an online reader store for its e-inked devices and companion apps. Any e-Books purchased will arrive ready-to-read on the Reader app or other suitably wireless device, with titles also working on any Adobe DRM-supported apps and devices. Sony's Reader app has benefited from a UI redesign, the addition of a landscape view and improved stability. Hit up the source to grab the update -- before your phone tells you to.

Continue reading Sony launches web store for e-Books, Android app also gets refresh

Sony launches web store for e-Books, Android app also gets refresh originally appeared on Engadget on Wed, 06 Jun 2012 10:31:00 EDT. Please see our terms for use of feeds.

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