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For years, a particular protein has been cast as a lynchpin of long-term memory. Inhibiting this enzyme could erase old memories, whereas adding it could strengthen faded ones. But two independent groups of US scientists have now seriously challenged the role of this 'memory molecule' by developing mice that completely lack it ? and showing that these mice have no detectable memory problems. Their results are published today in Nature.
The excitement around the enzyme, called protein kinase M-? (PKM-?), started building in 2007, when Todd Sacktor at the SUNY Downstate Medical Center in New York City wiped out month-old memories of unpleasant smells in rats. He did so by injecting their hippocampus ? a region of the brain crucial in memory formation ? with ZIP, a small peptide that is meant to block the enzyme.
Other teams obtained similar results, erasing different types of memory by injecting ZIP into various brain regions in rodents, flies and sea slugs. And in 2011, Sacktor did the opposite: he strengthened rats' memory of unpleasant tastes by injecting their brains with viruses carrying extra copies of PKM-?.
Memory surprise
These fascinating studies suggested that long-term memory, rather than being static and stable, is surprisingly fragile, and depends on the continuous activity of a single enzyme.
Richard Huganir of Johns Hopkins University in Baltimore, Maryland, was intrigued by these results, but was concerned that much of the data depended on the actions of ZIP. He and his collaborators took a different route, by deleting two genes ?? one for PKM-? and one for a related protein called PKC-? ? in embryonic mice. Working independently, Robert Messing and colleagues at the University of California, San Francisco, created similar mice.
Neither group of mice showed any memory problems. Messing?s animals formed persistent memories for fears, objects, places and movements across a battery of behavioral tests. And Huganir?s mice showed normal levels of long-term potentiation ? the strengthening of synapses between two neurons that is thought to underlie learning and memory.
?Our study pretty conclusively says that PKM-? does not regulate memory,? says Huganir. ?We were quite surprised.? Even more surprisingly, both teams found that ZIP could still disrupt established memories in their mice, despite their lack of PKM-?.
?Our study doesn?t rule out the possibility that PKM-? may play a role in some forms of memory, but it is not the essential master regulator of memory that the current literature suggests it to be,? says Lenora Volk, a member of Huganir?s team.
But Sacktor argues that the results are ?not too surprising? because a different gene might have compensated for the loss, as routinely happens in mice that have had some genes deleted. He suspects that related proteins like PKM-? or PKM-? may be involved. ?I think the future will be to try to find the back-up mechanisms for memory.?
Alternative pathways
However, Huganir?s team also created mice whose PKM-? gene could be deleted at will by giving them a specific drug. This allowed the researchers to deplete the enzyme during adulthood, after mice had grown up with normal levels. The animals still showed normal long-term potentiation.
Source: http://rss.sciam.com/click.phdo?i=b73745933f92a93dd9b004380095bb6b
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Source: http://video.msnbc.msn.com/cnbc/50355028/
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On Monday, the Academy of Motion Picture Arts and Sciences announced plans to extend the voting for Oscar nominations by 24 hours, to Jan. 4. The move comes as a sort of last-ditch effort to ease the transition from paper ballot voting to e-voting, which has been fraught with technical issues, including?log-in issues, voter ID mismatches and concerns of hacking. ?The Academy?s chief operating officer, Ric Robertson, said in a statement that ?By extending the voting deadline we are providing every opportunity available to make the transition to online balloting as smooth as possible.?
And indeed, the Academy has been working hard to make its first electronic vote seamless for its members, who, until Dec. 14 of this year, still had the option to vote via a paper ballot. According to the Hollywood Reporter:
A mailing went out several months ago offering members the option to vote by paper ballot, as long as they requested one by Nov. 30 ? a deadline that later was?extended?to Dec. 14. The Academy subsequently sent paper ballots to any members who paid their dues but never replied with a preference. It also set up e-voting stations in Los Angeles, New York and London, where Academy officials can help walk members through the process. And there?s also a toll-free help line, with Academy operators available 24/7.
But members reported technical issues soon after voting for the 85th Annual Academy Awards began on Dec. 17, telling the Hollywood Reporter that the e-voting system was so difficult to use that??There will probably be a large percentage of people who will just say, ?Screw it,? and not even vote this year.? Another ?member said, ?I have heard from several that it?s been a disaster and they wanted to give up. Confused and frustrated people will just not vote.?
Everyone Counts Inc., the electronic voting vendor partnering with longtime Academy ballot tabulator and accounting firm PricewaterhouseCoopers, has not yet commented on the system?s technical issues.
Analysts fear that the technical difficulties might shut out members from voting, particularly older members (the median age among Academy members is 62).?Scott Feinberg, awards analyst for the Hollywood Reporter, told the AP,??There?s considerable concern from many members that voter participation will be at record lows this year because the people who wanted to take a chance on this new cutting-edge system are either giving up on it or worried they won?t be able to cast their votes.? ?If the turnout is lower among older members,? Feinberg added, ?more traditional Oscar contenders will probably receive fewer votes, and otherwise edgier films that appeal more to younger people could fare better.?Because of the way that best-picture voting works, it could increase the chances of a movie like ?The Master? or ?Moonrise Kingdom? getting in.?
The online voting system will be closed between 5 p.m. to 7 p.m. PT on Thursday, Jan. 3, to maintain security and accommodate an extended deadline, and will remain open until 5 p.m. PT on Jan. 4.
Continue Reading CloseSource: http://www.rottentomatoes.com/m/1926574/news/1926574/
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President Obama and House Speaker John Boehner. (credit: Pool/Getty Images News)
SACRAMENTO (AP) ? The deal in Washington to avoid the ?fiscal cliff? will bring a reprieve to California?s slowly rebounding economy, but uncertainty remains in part because Congress delayed action on federal spending cuts.
The agreement helps California avoid sliding back into recession, H.D. Palmer, finance spokesman for Gov. Jerry Brown, said Wednesday.
But economic forecasters said the two-month delay on the sequestration cuts could lead businesses to delay hiring or investments.
?To the extent that this agreement averts a national recession ? and the revenue loss associated with it ? then we will have dodged a bullet,? Palmer said a day after Congress reached the deal.
One immediate benefit of the agreement is about 400,000 jobless Californians will receive extended unemployment benefits. The legislation also stops a 27 percent reduction in Medicare fees paid to doctors, and keeps in place a higher child tax credit as well as tax credits for college tuition, clean energy and small businesses.
While it raises taxes on the wealthy, the deal prevents most tax increases on the middle class. All taxpayers will be subject to an additional 2 percent Social Security payroll tax because Congress allowed that tax holiday to expire.
Individuals making $400,000 or more and couples making $450,000 or more will see an increase in their tax rate to 39.6 percent, up from 35 percent.
About 144,000 of the state?s 14.6 million tax returns, or 1 percent, reported incomes of $400,000 or more, according to 2009 statistics from the California Franchise Tax Board, the latest data available.
Forecasters had predicted California would fall back into recession if all the federal tax breaks were allowed to expire and government spending was slashed.
Some observers still fear the two-month delay in negotiations about spending and the federal debt could cause businesses and investors to hold back.
?Part of the fiscal cliff was postponed for two months, so it?s still there,? said Jerry Nickelsburg, economics professor at the UCLA Anderson School of Management. ?We just changed it from one fiscal cliff into two.?
The Los Angeles County Economic Development Corp. projected that automatic spending cuts would have brought a loss of $22.7 billion in gross state product ? the annual measure of goods and services produced in California. It also could have meant the loss of 225,000 jobs statewide.
The nonpartisan Legislative Analyst?s Office warned that California also could have lost as much as $11 billion in tax revenue if the nation fell back into recession. That would wipe out the bulk of tax gains under Proposition 30, a set of temporary sales and income taxes hikes voters approved in November.
(? Copyright 2013 The Associated Press. All Rights Reserved. This material may not be published, broadcast, rewritten or redistributed.)
Source: http://losangeles.cbslocal.com/2013/01/02/fiscal-cliff-deal-brings-some-relief-to-calif/
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Florida State quarterback EJ Manuel (3) looks to pass during the first half of the Orange Bowl NCAA college football game against Northern Illinois, Tuesday, Jan. 1, 2013, in Miami. (AP Photo/J Pat Carter)
Florida State quarterback EJ Manuel (3) looks to pass during the first half of the Orange Bowl NCAA college football game against Northern Illinois, Tuesday, Jan. 1, 2013, in Miami. (AP Photo/J Pat Carter)
Florida State fullback Lonnie Pryor (24) runs 60 yards for a touchdown during the first half of the Orange Bowl NCAA college football game against the Northern Illinois, Tuesday, Jan. 1, 2013, in Miami. (AP Photo/Alan Diaz)
Florida State fans cheer the arrival of the team before the Orange Bowl NCAA college football game against Northern Illinois, Tuesday, Jan. 1, 2013, in Miami. (AP Photo/J Pat Carter)
Northern Illinois fans cheer the arrival of the team before the Orange Bowl NCAA college football game against Florida State, Tuesday, Jan. 1, 2013, in Miami. (AP Photo/Alan Diaz)
Florida State defensive back Xavier Rhodes (27) is tended to by trainers on the field during the second half of the Orange Bowl NCAA college football game against Northern Illinois, Tuesday, Jan. 1, 2013, in Miami. (AP Photo/J Pat Carter)
MIAMI (AP) ? Anxious to avoid an Orange Bowl shocker, the Florida State Seminoles kept getting tricked.
An onside kick fooled them, as did a fake punt, and a pooch punt by Northern Illinois' star quarterback.
But the final score was no surprise. Florida State had too much speed and depth for the Huskies and pulled away for a 31-10 victory Tuesday night.
Senior fullback Lonnie Pryor, voted the game's outstanding player, ran for a career-high 134 yards and two scores in only five carries. Senior EJ Manuel threw for 291 yards, while the Seminoles stuffed Huskies' QB and all-purpose threat Jordan Lynch for most of the night.
"We came out here and did what we had to do," Pryor said.
The victory was a consolation prize for the No. 13 Seminoles (12-2), who began the season with national championship hopes. They've won five consecutive bowl games, but the victory was their first in a BCS bowl since 2000, when they beat Virginia Tech for the national championship.
For 16th-ranked Northern Illinois (12-2), playing in a BCS bowl for the first time, the defeat snapped a 12-game winning streak. The Huskies came in as two-touchdown underdogs and fell to 5-28 against top 25 teams.
"We knew that they was going to play us tough," Florida State coach Jimbo Fisher said. "But our kids, it's another step in which we handled the big platform, and I'm very proud of them."
Pryor scored the first touchdown on a career-long 60-yard run, then ran 37 yards for a clinching touchdown with 10 minutes left. They were the two longest rushes allowed by Northern Illinois all season.
"I'm glad I'm a Nole, and I'm glad the seniors went out with a bang," Pryor said. "I always wanted to be MVP of a bowl, and I told myself that every time I get the ball, to try to make a big play."
Manuel went 26 for 38, threw for one score and ran for another.
"We just kept playing," he said. "Now we're going to enjoy ourselves."
The Huskies were widely derided as unworthy of a BCS bowl berth, and didn't do enough to silence the doubters. They were outgained 534 yards to 259.
The trick plays in the kicking game helped keep the Huskies close until the fourth quarter, but when it came to Lynch, not much fooled a Seminoles defense ranked second in the nation. And the Huskies' last attempt at razzle-dazzle backfired when receiver Da'Ron Brown lost a fumble on an end around at midfield, setting up Florida State's final touchdown.
Lynch came into the game leading the nation in rushing and total offense, and he threw or ran on nearly every play for the Huskies. But he completed only 15 of 41 attempts for 176 yards, and carried 23 times for 44 yards.
The junior became the first player in NCAA history to surpass 3,000 yards passing and 1,500 rushing in a season.
After the Huskies' lone touchdown cut their deficit to 17-10 in the third quarter, they recovered an onside kick, and Lynch moved them to the Florida State 23. But he was flushed from the pocket on third down and threw an ill-advised pass that Terrence Brooks intercepted.
The loss was Rod Carey's debut as the Huskies' coach. He was promoted to replace Dave Doeren, who took the North Carolina State job after the regular season. Doeren watched the game from the stands.
When Florida State dropped no one deep defending an early fourth-and-1 situation, Lynch pooched a 52-yard punt that rolled dead at the 5. The poor field position didn't faze the Seminoles, who scored in four plays, the last when Pryor broke into the clear near midfield and outran the Huskies' secondary.
With the Seminoles up only 7-3, Manuel moved them 82 yards in the final 3:57 of the first half for another touchdown with 11 seconds left. He threw on the move for a 6-yard score to Rashad Greene, who managed to get one foot inbounds before he tumbled out of the end zone.
Desroy Maxwell took a short snap on a fake punt on fourth and 3 and ran 35 yards to set up a field goal for the Huskies' first score, but their offense struggled to sustain anything. Lynch passed, ran or punted on 28 of 29 plays for Northern Illinois' offense in the first half, and the Seminoles were geared to stop him.
He finally got the Huskies going in the third quarter, when they mounted an 87-yard touchdown drive. He threw deep to Akeem Daniels for 55 yards, then hit Martel Moore for an 11-yard score.
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January 1, 2013, 8:15 AM PST
Takeaway: The new trend in hiring in 2013? Challenge-based and video interviews. Read how you can master these new challenges.
Just when you got the hang of the in-person or phone interview, things are changing. According to HireArt, a company that helps employers make hires, the new trend in hiring in 2013 is utilizing challenge-based and video interviews.
?Businesses and recruiters are using video interviews and work samples as a way to effectively vet job candidates before bringing them in for an actual interview so employers can ?try before they buy? and ensure they?re finding the right candidate for the job.?
For example, if a business is hiring an engineer, they may present a coding challenge to candidates; if they?re hiring a social media manager they may ask candidates to create compelling tweets.
Here are some tips from HireArt to ensure that candidates are prepared for both the challenge-based and video interviews that are becoming more common in today?s competitive job market.
1. Act like you want to be there.
Being energetic over a video interview can go a long way in making you stand out against other candidates that seem bored or uncomfortable. Even though it might be more difficult to seem enthusiastic about a job when you are just talking to the camera, you should try to come across as excited and passionate about why you want to be there.
2. Watch your presentation.
You don?t look as good on camera as you look in person (it?s true!). So, don?t let basic components of your interview, such as attire and lighting, negatively affect how you come across. Dress as you would dress were the interview taking place in the office. Record the view in a bright place that allows the interviewer to clearly see you. And make sure the quality of your audio allows the interviewer to really understand what you are saying. Although these things are not related to your skills, they could count against you when other candidates have them and you don?t.
3. Don?t be sloppy.
Typos and lack of attention to detail in your online applications often immediately disqualify you. Take the time to be careful!
4. Know your own pitch.
Most video interviews require you to record a two minute pitch about yourself. Really think about what you want to get across, what experiences you would like to highlight, what sets you apart from other candidates, and how you want to say this in a succinct way.
5. Make sure you know the company, its competitors and the industry inside and out.
If you are invited to an interview, even if it is an online interview, companies expect you to understand the position and know the company well. Use this information to craft your pitch and at every other chance you get. Articulate specifically why you want to work at the company - what specifically drew you to this position.
Source: http://www.techrepublic.com/blog/career/master-the-changing-face-of-job-interviewing/4758
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